Chromatin Remodeling
Gene co-expression module in Natural Killer cells
| Category | DNA regulation & transcription |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes DEK (chromatin remodeling, oncogene), PSIP1 (LEDGF, chromatin-associated transcriptional coactivator), NUCKS1 (nuclear casein kinase substrate, chromatin accessibility), SMC1A (cohesin complex, DNA repair/cohesion), CBX5 (HP1alpha, heterochromatin), HMGB1 (chromatin architecture, DAMP), ANP32E (histone chaperone, H2A.Z exchange), COX8A (mitochondrial cytochrome c oxidase subunit - peripheral member), CALM3 (calmodulin), NUCB2 (nucleobindin). The dominant program is chromatin organization and nuclear architecture, with multiple histone/chromatin regulators. The module is upregulated in CD inflammation. COX8A and CALM3 are peripheral members. This module reflects active chromatin remodeling and nuclear organization in proliferating/activated NK cells.
Genes
ANP32E, CALM3, CBX5, COX8A, DEK, HMGB1, NUCB2, NUCKS1, PSIP1, SMC1A
Most correlated modules
- G2/M Transition · correlation 0.93
- Glycolytic Metabolism · correlation 0.87
- S-phase Replication · correlation 0.84
- DNA Replication · correlation 0.82
- hnRNP RNA Processing · correlation 0.80
- Mitotic Spindle · correlation 0.79
- Immunoproteasome Activation · correlation 0.78
- Oxidative Stress Response · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.