G2/M Transition
Gene co-expression module in Natural Killer cells
| Category | Cell cycle |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes TMPO (lamina-associated polypeptide 2, nuclear envelope/cell cycle), SMC2 (condensin complex, chromosome condensation), STMN1 (stathmin, microtubule destabilizer, cell cycle), TUBA1B and TUBB (tubulin subunits, mitotic spindle), NSD2 (histone methyltransferase, chromatin), ANP32B (histone chaperone), CARHSP1 (mRNA stability), PHF19 (PRC2 complex). This module combines mitotic spindle/chromosome segregation components (STMN1, TUBA1B, TUBB, SMC2) with chromatin regulators (NSD2, PHF19, ANP32B). The neighbor context (M26 chromatin, M73/M44/M41 cell cycle) confirms this is a cell cycle-associated program, specifically S/G2/M transition with microtubule and chromatin condensation components. Downregulated in remission, upregulated in inflammation.
Genes
ANP32B, CARHSP1, NSD2, PHF19, SMC2, STMN1, TMPO, TUBA1B, TUBB
Most correlated modules
- S-phase Replication · correlation 0.94
- Chromatin Remodeling · correlation 0.93
- Mitotic Spindle · correlation 0.90
- DNA Replication · correlation 0.88
- Replication Histones · correlation 0.83
- Glycolytic Metabolism · correlation 0.75
- Energy Metabolism · correlation 0.63
- Immunoproteasome Activation · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.