S-phase Replication
Gene co-expression module in Natural Killer cells
| Category | Cell cycle |
|---|---|
| Genes | 8 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
All hub genes are canonical S-phase/DNA replication and replication stress markers: CENPU and CENPM (kinetochore/centromere proteins), CLSPN (claspin, replication checkpoint), CDT1 (replication licensing factor), FANCI (Fanconi anemia DNA repair), TYMS (thymidylate synthase, dNTP synthesis), PCLAF (PCNA-associated factor, S-phase), RRM2 (ribonucleotide reductase, dNTP synthesis). This is a tightly coherent S-phase DNA replication module. Downregulated in remission, consistent with reduced NK cell proliferation during disease quiescence.
Genes
CDT1, CENPM, CENPU, CLSPN, FANCI, PCLAF, RRM2, TYMS
Most correlated modules
- DNA Replication · correlation 0.97
- G2/M Transition · correlation 0.94
- Chromatin Remodeling · correlation 0.84
- Replication Histones · correlation 0.83
- Mitotic Spindle · correlation 0.77
- Glycolytic Metabolism · correlation 0.68
- Histone Variant Remodeling · correlation 0.65
- Replication-Coupled Histones · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.