TGFB-Collagen Remodeling
Gene co-expression module in Smooth muscle cells
| Category | ECM remodeling |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
TGFB3 and COL14A1 (core membership) anchor a TGF-beta-driven fibrillar matrix program; VASN (vasorin, TGF-beta binding protein), IGFBP2, VGLL3 (pro-fibrotic TEAD cofactor) and the actin-associated LASP1/TPM3 complete a myofibroblast-like ECM/contractile-remodelling state. This fits the neighborhood of matricellular (M54) and secretory (M22) modules and represents a synthetic SMC/fibromyocyte phenotype.
Genes
COL14A1, IGFBP2, LASP1, SYTL2, TGFB3, TPM3, VASN, VGLL3
Most correlated modules
- BMP-ID3 Matricellular · correlation 0.75
- Pericyte Basement Membrane · correlation 0.68
- ER-Golgi Secretory · correlation 0.60
- Calcium Handling · correlation 0.59
- ER-Golgi Secretory Pathway · correlation 0.58
- NF-kB Stress Response · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.