Calcium Handling
Gene co-expression module in Smooth muscle cells
| Category | Contractility |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
The functionally informative hubs are excitation-contraction coupling genes: RYR2 (sarcoplasmic Ca2+ release), SCN4B (voltage-gated sodium channel beta subunit), PDE1A (Ca2+/calmodulin-stimulated phosphodiesterase controlling cGMP/cAMP tone), and RBM24 (muscle-specific RNA-binding protein required for sarcomeric/contractile transcript stability), with RRAS/ASAP2 (Rap-Arf adhesion signaling) and TMTC1 (ER Ca2+ homeostasis/O-mannosylation). This is a calcium-handling/electromechanical coupling program in smooth muscle, complementary to the contractile identity module M97 in the same neighborhood; remaining genes (MYCBP2, DDX24, NBDY, SMIM12) are generic and lower the coherence.
Genes
ASAP2, DDX24, MYCBP2, NBDY, PDE1A, RBM24, RNF180, RRAS, RYR2, SCN4B, SMIM12, TMTC1
Most correlated modules
- Contractile SMC Identity · correlation 0.82
- Pericyte Notch Identity · correlation 0.70
- Mural/Pericyte Identity · correlation 0.70
- Vascular Tone Signaling · correlation 0.66
- Pericyte Basement Membrane · correlation 0.64
- Immediate Early Response · correlation 0.60
- TGFB-Collagen Remodeling · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.