BMP-ID3 Matricellular
Gene co-expression module in Smooth muscle cells
| Category | Development |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes ID3 (BMP-induced HLH inhibitor) together with DKK3 (Wnt antagonist), SMOC2 and HAPLN3 (matricellular/hyaluronan-link proteins) define a BMP/Wnt-modulated matricellular program; TAGLN2, SH3BGRL3, ANXA1 and STOM are membrane/actin-associated genes typical of a synthetic/adventitial mural state. Its neighbor M22 contains BMP2 and other secretory genes, supporting a shared BMP-signalling axis rather than a contamination or stress program. Coherence strong but the gene set spans signalling and matrix, so certainty is moderate.
Genes
ANXA1, DKK3, HAPLN3, ID3, SH3BGRL3, SMOC2, STOM, TAGLN2
Most correlated modules
- Activated Myofibroblast · correlation 0.77
- Endolysosomal Trafficking · correlation 0.76
- TGFB-Collagen Remodeling · correlation 0.75
- Pericyte Basement Membrane · correlation 0.70
- Pericyte Notch Identity · correlation 0.69
- ER-Golgi Secretory · correlation 0.68
- Type I Interferon · correlation 0.67
- XBP1 UPR Response · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.