ER-Golgi Secretory Pathway
Gene co-expression module in Smooth muscle cells
| Category | Protein processing & ER |
|---|---|
| Genes | 13 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
Hub IFT57 is nonspecific, but the bulk of the module converges on the secretory/ER-Golgi protein-handling axis: LRPAP1 (ER chaperone for LRP receptors), KDELR2 (ER retrieval receptor, strongly linked to collagen secretion), PAM (secretory peptide amidating monooxygenase), CCT3 (chaperonin/TRiC folding), BZW1 (translation initiation), plus secreted/matrix cargo (COL15A1, PI15, GPC6). UBE2M/PHC2/XRN2/NFATC4 are peripheral housekeeping-regulatory genes, consistent with the moderate coherence and uniform, low-level expression. As a neighbor of the mural-identity module M0 and the activated/stress module M21, this looks like the biosynthetic-secretory arm supporting matrix output rather than a distinct lineage or artifact.
Genes
BZW1, CCT3, COL15A1, GPC6, IFT57, KDELR2, LRPAP1, NFATC4, PAM, PHC2, PI15, UBE2M, XRN2
Most correlated modules
- Activated Myofibroblast · correlation 0.76
- Redox-Metabolic Housekeeping · correlation 0.76
- ER Chaperone/UPR · correlation 0.70
- Pericyte Vasoregulatory Identity · correlation 0.68
- TGFB-Collagen Remodeling · correlation 0.58
- ER-Golgi Secretory · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.