NF-kB Stress Response
Gene co-expression module in Smooth muscle cells
| Category | Stress |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Core module dominated by NF-kB/stress-inducible early genes: NFKBIZ (IkB-zeta), IER3, PPP1R15A (GADD34, integrated stress response), MIDN, BHLHE40 (hypoxia/stress bHLH), CCNL1 (transcription-coupled early gene), THBS1 (TGF-beta activating matricellular stress gene) plus HSP90AB1 and lipid-metabolic stress genes UGCG/FADS3. Uniform expression, no lineage marker enrichment. Sits adjacent to the canonical IEG module M79 and the NR4A module M28, consistent with a second, slightly later NF-kB/ISR arm of the same dissociation/activation cascade rather than a distinct inflammatory phenotype.
Genes
BHLHE40, CCNL1, FADS3, HSP90AB1, IER3, MIDN, NFKBIZ, PPP1R15A, THBS1, UGCG
Most correlated modules
- NR4A-ADAMTS Activation · correlation 0.77
- XBP1 UPR Response · correlation 0.76
- Immediate Early Response · correlation 0.71
- Secondary Response Genes · correlation 0.67
- STAT3 transcriptional program · correlation 0.63
- BAG3-HSPB8 proteostasis · correlation 0.62
- Immediate Early Response · correlation 0.61
- BMP/TGF-beta response · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.