COL14A1 — Collagen type XIV alpha 1 chain
COL14A1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COL14A1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Pericytes | Pericyte ECM Production ECM production | AEBP1, CALD1, GUCY1B1, LURAP1L, PMP22, SDC2, TPPP3, VCL | View in SCUBA |
| Smooth muscle cells | TGFB-Collagen Remodeling ECM remodeling | IGFBP2, LASP1, SYTL2, TGFB3, TPM3, VASN, VGLL3 | View in SCUBA |
About the gene
| Synonyms | UND |
|---|---|
| Chromosome | 8: 120059780-120373573 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Cell adhesion |
Function
Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.