ER-Golgi Secretory
Gene co-expression module in Smooth muscle cells
| Category | Protein processing & ER |
|---|---|
| Genes | 9 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Low-coherence module whose members converge on the secretory/membrane-biogenesis machinery: YIF1A (ER-Golgi vesicle transport), ATP2A2 (SERCA2 ER calcium pump), ARL2 (ARF-like GTPase, membrane traffic/tubulin folding), LAMB2 (secreted basement-membrane laminin), CD46 (complement regulatory membrane protein), SPTB (membrane skeleton). BMP2 and PLXND1 link it to the BMP/guidance signalling seen in neighbor M54, and ATP2A2/YIF1A tie it to the XBP1-HERPUD1 ER module M29. Best read as a low-amplitude ER-Golgi secretory/membrane program rather than a discrete stress or contamination signature.
Genes
ARL2, ATP2A2, BMP2, CD46, LAMB2, PLXND1, RNASEH2C, SPTB, YIF1A
Most correlated modules
- Pericyte Basement Membrane · correlation 0.70
- BMP-ID3 Matricellular · correlation 0.68
- Actin Cytoskeletal Scaffold · correlation 0.63
- TGFB-Collagen Remodeling · correlation 0.60
- Redox-Metabolic Housekeeping · correlation 0.60
- Lipid Kinase Signaling · correlation 0.59
- ER-Golgi Secretory Pathway · correlation 0.58
- KLF6/ZNF24 regulators · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.