OxPhos & Translation
Gene co-expression module in Smooth muscle cells
| Category | Housekeeping |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 12 genes have a known function matching the annotation |
Why this annotation
Combines complex III/IV/I subunits (COX7C, COX6B1, UQCR11, NDUFA13) with small translation/secretion-associated housekeeping genes (SRP14, EIF3H, TMA7, EDF1, ELOB, COMMD6, WDR83OS). All uniform, short, highly detected transcripts — a classic 'small housekeeping gene' co-detection axis strongly overlapping the OxPhos module M70. Interpreted as a mixed energy-metabolism/basal translation housekeeping program.
Genes
COMMD6, COX6B1, COX7C, DYNLT1, EDF1, EIF3H, ELOB, NDUFA13, SRP14, TMA7, UQCR11, WDR83OS
Most correlated modules
- Respiratory Chain Subunits · correlation 0.94
- Mitochondrial Housekeeping · correlation 0.91
- Ubiquitous Housekeeping Transcripts · correlation 0.90
- Basal Maintenance Genes · correlation 0.89
- Basal Metabolic Housekeeping · correlation 0.88
- OXPHOS Complex I · correlation 0.87
- Rho GTPase Housekeeping · correlation 0.87
- Translation elongation housekeeping · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.