Rho GTPase Housekeeping
Gene co-expression module in Smooth muscle cells
| Category | Housekeeping |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
Small ubiquitously expressed transcripts: CDC42 and RHOC (Rho-family GTPases regulating actin/cytoskeletal dynamics) head the module, but the rest are canonical high-abundance housekeeping genes (POLR2L RNA Pol subunit, OST4 oligosaccharyltransferase, PRELID1 mitochondrial lipid transfer, SCAND1, DDT, CST3 secreted cystatin). Uniform expression with no subset enrichment and high detection rate indicate a general maintenance/co-detection program rather than an activated migratory state. Shares its cytoskeletal-GTPase flavor with neighbor M99 (CFL1/CAPZA2), consistent with a common baseline actin-regulatory housekeeping axis in smooth muscle cells.
Genes
CDC42, CST3, DDT, OST4, POLR2L, PRELID1, RHOC, SCAND1
Most correlated modules
- OxPhos & Translation · correlation 0.87
- Proteasome And Translation · correlation 0.87
- Actin Dynamics Housekeeping · correlation 0.84
- Respiratory Chain Subunits · correlation 0.84
- Mitochondrial Housekeeping · correlation 0.82
- Endolysosomal Trafficking · correlation 0.80
- Translocon & Proteostasis · correlation 0.80
- Membrane Protein Turnover · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.