WDR83OS — WD repeat domain 83 opposite strand
WDR83OS belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
WDR83OS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Oxidative Phosphorylation Mitochondrial & OxPhos | ARPC1B, ARPC4, ATP6V1F, COPE, COX6A1, COX6B1, COX6C, CSNK2B +12 more | |
| Innate lymphoid cells | Mitochondrial OxPhos Mitochondrial & OxPhos | AKR7A2, ANXA6, AP2M1, ARL6IP4, ARPC1B, ATP5MC2, ATP5PB, BSG +21 more | View in SCUBA |
| Macrophages | Mixed Housekeeping Housekeeping | AP2M1, BAG1, CHMP4A, CISD2, COA6, CSNK2B, CYB5R3, DEGS1 +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | ER Glycosylation & Ubiquitin Protein processing & ER | AIP, ALDOA, ATP5MG, COX6A1, COX6B1, ELOB, FIS1, GAPDH +9 more | |
| Smooth muscle cells | OxPhos & Translation Housekeeping | COMMD6, COX6B1, COX7C, DYNLT1, EDF1, EIF3H, ELOB, NDUFA13 +3 more | View in SCUBA |
About the gene
| Synonyms | Asterix, C19orf56, PTD008 |
|---|---|
| Chromosome | 19: 12668073-12669415 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Molecular function | Chaperone |
Function
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein (By similarity). Within the PAT subcomplex, WDR83OS/Asterix binds to and redirects the substrate to a location behind the SEC61 complex (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.