Mitochondrial Housekeeping
Gene co-expression module in Smooth muscle cells
| Category | Housekeeping |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 11 genes have a known function matching the annotation |
Why this annotation
Mixed ubiquitous program anchored by ETC subunits (UQCRH, NDUFAB1, COX7A2L) plus glycolysis (PGAM1), ER/secretory (SPCS2, TMEM14C, APP), autophagy (GABARAPL2), mTORC1 scaffold (LAMTOR4) and translation (EIF5B, TRMT112). Uniform across subsets, low-moderate expression; shares the mitochondrial backbone of M70/M120, so best read as a general mitochondrial/metabolic housekeeping module.
Genes
APP, COX7A2L, EIF5B, GABARAPL2, LAMTOR4, NDUFAB1, PGAM1, SPCS2, TMEM14C, TRMT112, UQCRH
Most correlated modules
- OXPHOS Complex I · correlation 0.91
- OxPhos & Translation · correlation 0.91
- Respiratory Chain Subunits · correlation 0.89
- Ubiquitous Housekeeping Transcripts · correlation 0.89
- Basal Metabolic Housekeeping · correlation 0.87
- Actin Dynamics Housekeeping · correlation 0.85
- Endolysosomal Trafficking · correlation 0.84
- Translocon & Proteostasis · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.