Basal Metabolic Housekeeping
Gene co-expression module in Smooth muscle cells
| Category | Housekeeping |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 15 genes have a known function matching the annotation |
Why this annotation
No dominant pathway: proteasome assembly chaperone (POMP), glycolysis (PKM, GUK1), mitochondrial assembly (COX17, MRPL51), actin/Rho machinery (RAC1, ARPC2), RNA-binding (CNBP, HNRNPH2, HNRNPDL) and uncharacterized ubiquitous ORFs (C11orf58, C4orf3, C1orf43). Uniform expression, moderate detection — a generic basal metabolic/housekeeping axis, consistent with neighboring housekeeping modules rather than a specific smooth-muscle program.
Genes
ARPC2, C11orf58, C1orf43, C4orf3, CNBP, COX17, GUK1, HNRNPDL, HNRNPH2, MAF1, MRPL51, PKM, POMP, RAC1, SARAF
Most correlated modules
- Respiratory Chain Subunits · correlation 0.91
- Ubiquitous Housekeeping Transcripts · correlation 0.90
- OXPHOS Complex I · correlation 0.89
- OxPhos & Translation · correlation 0.88
- Mitochondrial Housekeeping · correlation 0.87
- Actin Dynamics Housekeeping · correlation 0.86
- mRNA Splicing Factors · correlation 0.84
- Basal Maintenance Genes · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.