OXPHOS Complex I
Gene co-expression module in Smooth muscle cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
Four nuclear-encoded respiratory chain complex I subunits (NDUFC2, NDUFB10, NDUFA2) plus ETFB (electron transfer flavoprotein, beta-oxidation to respiratory chain) and MRPS21 (mitoribosome) anchor a mitochondrial energy-metabolism signature, with peripheral small housekeeping genes (VPS28, COPS6, SBDS, CLTB, IAH1, SIVA1, OAT). Uniform expression, no lineage-specific enrichment. Neighboring modules M86 and M48 also carry OXPHOS subunits (NDUFB8, COX8A, COX14), indicating this neighborhood is organized around mitochondrial/housekeeping transcript abundance; this module is the most OXPHOS-weighted member.
Genes
CLTB, COPS6, ETFB, IAH1, MRPS21, NDUFA2, NDUFB10, NDUFC2, OAT, SBDS, SIVA1, VPS28
Most correlated modules
- Mitochondrial Housekeeping · correlation 0.91
- Ubiquitous Housekeeping Transcripts · correlation 0.91
- Respiratory Chain Subunits · correlation 0.90
- Basal Metabolic Housekeeping · correlation 0.89
- Basal Maintenance Genes · correlation 0.88
- OxPhos & Translation · correlation 0.87
- Myogenic Cytoskeletal Program · correlation 0.82
- Actin Dynamics Housekeeping · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.