Respiratory Chain Subunits
Gene co-expression module in Smooth muscle cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 5 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes are nuclear-encoded oxidative phosphorylation subunits (COX6A1, COX7B, UQCRQ, UQCR10, NDUFB1) co-expressed with a handful of small ubiquitous housekeeping transcripts (SNX3, PFN1, SNRPD2, MZT2B, UBXN1, C19orf53). Uniform detection across all subsets with no lineage enrichment indicates a global metabolic/housekeeping axis rather than a cell-state program. Neighbors M120/M62 share the same ETC-subunit backbone, supporting an OxPhos-dominated co-expression neighborhood.
Genes
C19orf53, COX6A1, COX7B, MZT2B, NDUFB1, PFN1, SNRPD2, SNX3, UBXN1, UQCR10, UQCRQ
Most correlated modules
- OxPhos & Translation · correlation 0.94
- Basal Metabolic Housekeeping · correlation 0.91
- Ubiquitous Housekeeping Transcripts · correlation 0.90
- OXPHOS Complex I · correlation 0.90
- Mitochondrial Housekeeping · correlation 0.89
- Actin Dynamics Housekeeping · correlation 0.89
- Basal Maintenance Genes · correlation 0.86
- mRNA Splicing Factors · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.