Ubiquitous Housekeeping Transcripts
Gene co-expression module in Smooth muscle cells
| Category | Housekeeping |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
Hubs are small, ubiquitously expressed housekeeping transcripts spanning chaperone/folding (PFDN5), redox/detoxification (GSTP1, ISCU), proteasome (PSMA7, UBL5), lysosomal V-ATPase (ATP6V1G1), mitochondrial (NDUFB8, FIS1) and cold/stress-responsive RNA-binding (CIRBP, NUPR1) functions. No single pathway dominates, expression is uniform and high with broad detection — the hallmark of a generic 'small housekeeping gene' co-detection program rather than a specific biological state. Its neighbors M101 and M48 are likewise mixtures of OXPHOS subunits and small ubiquitous genes, supporting a shared housekeeping/transcript-abundance axis rather than a stress program.
Genes
ATP6V1G1, C12orf57, CIRBP, FIS1, GSTP1, ISCU, NDUFB8, NUPR1, PEBP1, PFDN5, PSMA7, UBL5
Most correlated modules
- OXPHOS Complex I · correlation 0.91
- Respiratory Chain Subunits · correlation 0.90
- OxPhos & Translation · correlation 0.90
- Basal Metabolic Housekeeping · correlation 0.90
- Mitochondrial Housekeeping · correlation 0.89
- Basal Maintenance Genes · correlation 0.87
- Endolysosomal Trafficking · correlation 0.82
- Glucocorticoid Metallothionein Response · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.