Translation elongation housekeeping
Gene co-expression module in Smooth muscle cells
| Category | Housekeeping |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes are canonical high-abundance housekeeping transcripts: translation elongation factors (EEF1A1, EEF1D, EEF2), ribosome-associated scaffold RACK1, TPT1, PTMA, SERF2, glycolytic GAPDH, iron-storage FTH1/FTL and mitochondrial carriers/import components (SLC25A6, TOMM7, COX4I1). All are uniformly expressed with very high detection (88%), a classic signature of the 'housekeeping/ambient high-expressor' axis rather than a regulated biological program. Its neighbors (contractile M16, MHC-I M88) are also uniform high-expression modules, consistent with a shared library-size/technical-covariance backbone driving the co-expression in this neighborhood.
Genes
COX4I1, EEF1A1, EEF1D, EEF2, FTH1, FTL, GAPDH, PTMA, RACK1, SERF2, SLC25A6, TOMM7, TPT1
Most correlated modules
- OxPhos & Translation · correlation 0.85
- Calcium Handling Contractile · correlation 0.84
- SMC contractile apparatus · correlation 0.83
- Ribonucleoprotein & translation · correlation 0.83
- Respiratory Chain Subunits · correlation 0.82
- OxPhos & proteasome · correlation 0.82
- Translocon & Proteostasis · correlation 0.82
- Ubiquitous Housekeeping Transcripts · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.