Pericellular Proteolysis
Gene co-expression module in Smooth muscle cells
| Category | ECM remodeling |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
MMP14 (MT1-MMP, pericellular collagenolysis), HTRA1 (matrix serine protease), CTSA (lysosomal protective protein/cathepsin A), plus SNX9 (membrane remodeling/invadopodia), AHNAK2 and S100A16 and the fibroblast/mesenchymal TF BNC2 define an active matrix-proteolysis/invasive remodeling program. Moderate coherence with TMED10 (secretory pathway) as a peripheral member. Sits directly adjacent to the matrix-deposition modules M35/M49, representing the degradative side of the same remodeling axis.
Genes
AHNAK2, BNC2, CRYBG3, CTSA, HTRA1, MMP14, S100A16, SNX9, TMED10
Most correlated modules
- Mesenchymal Adhesion Program · correlation 0.83
- Basement Membrane Matrix · correlation 0.82
- Lysosomal Glycoprotein Catabolism · correlation 0.80
- Matrix-integrin interaction · correlation 0.79
- Fibroblast-like Activation · correlation 0.77
- Matrix Crosslinking Activation · correlation 0.74
- SMC focal adhesion · correlation 0.73
- SMC Contractile Signaling · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.