Mesenchymal Adhesion Program
Gene co-expression module in Smooth muscle cells
| Category | Migration & adhesion |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes CDH11 (OB-cadherin, mesenchymal cell-cell adhesion), ANTXR1/TEM8 (collagen VI receptor), COL12A1 (FACIT collagen), RAB31 and CTSB/PLD3 (lysosomal trafficking), FSTL3 (TGF-beta/activin modulator) and FHL3 (focal adhesion LIM protein) define an adhesive, matrix-interacting mesenchymal program typical of synthetic/myofibroblast-like SMC. Uniform expression, no lineage-foreign subset enrichment, so this is a cell-state program rather than contamination. Neighbors M35, M42, M49 are also matrix/adhesion modules, supporting a shared synthetic-mesenchymal neighborhood; M10 is the adhesion/receptor arm.
Genes
ANTXR1, BAG2, CDH11, COL12A1, CTSB, FHL3, FSTL3, HEPH, PIM1, PKIG, PLD3, PTTG1IP, RAB31, REXO2, TSPAN2
Most correlated modules
- Pericellular Proteolysis · correlation 0.83
- Basement Membrane Matrix · correlation 0.81
- SMC focal adhesion · correlation 0.80
- Matrix-integrin interaction · correlation 0.80
- Contractile SMC phenotype · correlation 0.77
- Fibroblast-like Activation · correlation 0.77
- Lysosomal Glycoprotein Catabolism · correlation 0.77
- Basal metabolic housekeeping · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.