SMC focal adhesion
Gene co-expression module in Smooth muscle cells
| Category | Migration & adhesion |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 16 genes have a known function matching the annotation |
Why this annotation
Core members TGFB1I1 (Hic-5, focal adhesion adaptor and SMC differentiation cofactor), CD99, ANXA6 (membrane/cytoskeleton-linked calcium-dependent annexin of SMC), KANK1 (talin-binding focal adhesion protein) and RBPMS (master splicing regulator of the SMC contractile program) point to a focal-adhesion/SMC-differentiation module. A second, weaker component (MORF4L2, DNAJC1, PFDN1, VCP, HSBP1, ILF-like chaperone/proteostasis genes) explains the only moderate coherence, i.e. a mixed adhesion + housekeeping chaperone module. Given neighbors M19 (contractile) and M47 (integrin adhesion), the adhesion/differentiation interpretation is favored.
Genes
ANXA6, ARMCX6, C1orf21, CD99, DNAJC1, HSBP1, KANK1, MORF4L2, PFDN1, RBM38, RBMS1, RBPMS, RCN2, TGFB1I1, VCP, ZMIZ1
Most correlated modules
- Lysosomal Glycoprotein Catabolism · correlation 0.89
- Integrin adhesion complex · correlation 0.85
- Microtubule biogenesis · correlation 0.81
- Matrix-integrin interaction · correlation 0.81
- Basement Membrane Matrix · correlation 0.81
- Mesenchymal Adhesion Program · correlation 0.80
- Basal metabolic housekeeping · correlation 0.78
- Proteasome And Translation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.