Matrix Crosslinking Activation
Gene co-expression module in Smooth muscle cells
| Category | ECM remodeling |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
LOXL2 (collagen/elastin crosslinking), VCAN (versican, provisional matrix proteoglycan), COL23A1, ADAM19 (sheddase) and RCN1 (ER calcium-binding secretory chaperone) define an activated matrix-remodeling/synthetic state, while FOXF1 and NKX2-3 anchor gut mesenchymal identity. Adjacent to M119 (collagen deposition) and M30 (FOXF2 patterning), suggesting one axis of gut mesenchymal identity plus matrix remodeling; here the crosslinking/proteoglycan component dominates.
Genes
ADAM19, COL23A1, FOXF1, LOXL2, NKX2-3, PLPP1, RCN1, VCAN
Most correlated modules
- Microfibril ECM Assembly · correlation 0.89
- Synthetic Matrix Phenotype · correlation 0.87
- Neural Adhesion Program · correlation 0.86
- FOXF2 Mesenchymal Patterning · correlation 0.85
- Lysosomal Glycoprotein Catabolism · correlation 0.84
- Collagen-Laminin Deposition · correlation 0.83
- Notch-TGFbeta Signaling · correlation 0.77
- Basement Membrane Matrix · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.