Notch-TGFbeta Signaling
Gene co-expression module in Smooth muscle cells
| Category | Development |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
JAG1 (Notch ligand), TGFB2, TBX2, GJC1 (connexin 45) and ACKR3 (CXCR7) form a coherent developmental signalling program: Notch-TGFβ crosstalk is the core pathway driving mural cell differentiation and maturation, and TBX2/CSRNP3/LRRC10B are downstream transcriptional effectors. AFAP1L2, RAP2A and SNRK are signalling adaptors. Sits adjacent to the NOTCH3/MCAM mural identity module M100, which supports a Notch-ligand/TGFβ signalling counterpart rather than a stress or contractile program.
Genes
ACKR3, AFAP1L2, CSRNP3, GJC1, HTR1F, JAG1, LRRC10B, RAP2A, SLC38A11, SNRK, TBX2, TGFB2
Most correlated modules
- Pericyte Signature · correlation 0.86
- Capillary Pericyte · correlation 0.85
- Mural/Pericyte Identity · correlation 0.80
- Arteriolar Mural Cells · correlation 0.79
- Wnt-Notch Modulation · correlation 0.75
- Vasoconstrictor Signaling · correlation 0.73
- HOX Positional Identity · correlation 0.72
- Cytoskeletal Scaffolding · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.