PROM1 — Prominin 1
PROM1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PROM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Translational repression RNA processing & translation | B3GALT5, CDHR1, EEF2K, FAM13A, PDCD4, PLCL2, PTPRJ | View in SCUBA |
| Goblet cells | Inflammatory Goblet Remodeling Stress | C2CD4A, CLCA1, COL16A1, FMOD, GALNT8, GPX2, IFITM2, KCNE3 +3 more | View in SCUBA |
| Hematopoietic progenitor cells | Multipotent Progenitor State Stemness | CD44, CD99, FLT3, GBP2, GLIPR1, IL6R, PLCB1, PRAM1 | |
| Smooth muscle cells | Microfibril ECM Assembly ECM remodeling | ADAM28, FBN2, ITGA9, NEO1, NID1, PSD3, SERPINE2, SPON1 +2 more | View in SCUBA |
About the gene
| Synonyms | AC133, CD133, CORD12, MCDR2, PROML1, RP41, STGD4 |
|---|---|
| Chromosome | 4: 15963076-16084378 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
Function
May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol- containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.