SEMA6D — Semaphorin 6D
SEMA6D belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SEMA6D's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Colonocyte differentiation signaling Epithelial development | APPL2, BTBD9, BTNL8, CA13, CRACD, DENND5B, LUZP1, NEDD4 +2 more | View in SCUBA |
| Fibroblasts | Stromal Niche Signaling Developmental | ARHGAP20, COL15A1, CPNE8, IL7, ITIH5, KCNS3, KITLG, LIFR +7 more | View in SCUBA |
| Glial cells | Glial Neural Scaffolding Cytoskeletal | AKAP6, ARHGAP24, COL5A3, EIF4G2, NFIX, PPP1R12B, SCAF11, USP53 | View in SCUBA |
About the gene
| Synonyms | FLJ11598, KIAA1479 |
|---|---|
| Chromosome | 15: 47184101-47774228 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Developmental protein |
| Biological process | Differentiation, Neurogenesis |
Function
Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Ligand of TREM2 with PLXNA1 as coreceptor in dendritic cells, plays a role in the generation of immune responses and skeletal homeostasis (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.