VPS13A — Vacuolar protein sorting 13 homolog A
VPS13A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
VPS13A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Apical junction complex Migration & adhesion | ARHGAP32, HEPH, KDM6A, KIAA1671, MYH14, NIPBL, PLEKHA7, POF1B +3 more | View in SCUBA |
| Gamma-delta T cells | Centrosome Organization DNA/chromatin regulation | AKAP9, ARMCX6, CCNT2, CEP350, CUL5, DDHD1, DDX42, DENND6A +23 more |
About the gene
| Synonyms | BLTP5A, CHAC, KIAA0986 |
|---|---|
| Chromosome | 9: 77177445-77421537 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters |
| Biological process | Lipid transport, Transport |
Function
Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phospholipids. Required for the formation or stabilization of ER- mitochondria contact sites which enable transfer of lipids between the ER and mitochondria. Negatively regulates lipid droplet size and motility. Required for efficient lysosomal protein degradation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.