Ribosome Biogenesis
Gene co-expression module in Colonocytes
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
NIFK (Ki-67-interacting factor, 60S ribosome biogenesis), RSL24D1 (60S ribosomal subunit biogenesis), KRR1 (rRNA processing, 40S biogenesis), ZPR1 (ribosome biogenesis, SMA-related), and UTP18 (U3 snoRNP, 18S rRNA processing) form a coherent ribosome biogenesis core. YRDC (tRNA modification, threonylcarbamoyladenosine synthesis) and TRMT10C (mitochondrial tRNA methyltransferase) add tRNA modification. EIF2S3 (eIF2 gamma subunit, translation initiation) and EEF1E1 (translation quality control/aminoacyl-tRNA synthetase complex) link to translation. CCDC59 (top hub, interacts with eIF3/translation regulation) ties the module together. This is a tight ribosome biogenesis and tRNA modification module active in proliferating crypt cells.
Genes
Most correlated modules
- Cell Cycle Machinery · correlation 0.95
- eIF3 Translation Initiation · correlation 0.95
- snRNP Splicing · correlation 0.95
- SUMOylation Chromatin · correlation 0.95
- Ribosome Biogenesis · correlation 0.94
- CCT Chaperonin Folding · correlation 0.94
- RNA Processing Translation · correlation 0.94
- SWI-SNF DNA Repair · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.