SUMOylation Chromatin
Gene co-expression module in Colonocytes
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
Top hub UBA2 is the SUMO-activating enzyme E1 subunit, the initiating enzyme of the SUMOylation cascade. NUCKS1 is a chromatin-associated substrate of SUMOylation involved in DNA damage response. SSRP1 (FACT complex histone chaperone) and ANP32B (chromatin regulator) indicate active chromatin remodeling. PPIH (cyclophilin H) participates in spliceosome assembly. HNRNPR and ALYREF are RNA processing/export factors. CNOT7 (CCR4-NOT deadenylase) and UTP18 (rRNA processing) are additional RNA metabolism genes. POLE3 (DNA polymerase epsilon subunit) links to DNA replication. The SUMOylation machinery (UBA2) combined with chromatin remodeling (SSRP1, NUCKS1, ANP32B) in proliferating crypt cells defines this module.
Genes
Most correlated modules
- SWI-SNF DNA Repair · correlation 0.96
- Ribosome Biogenesis · correlation 0.96
- snRNP Splicing · correlation 0.96
- CCT Chaperonin Folding · correlation 0.95
- Ribosome Biogenesis · correlation 0.95
- Cell Cycle Machinery · correlation 0.95
- eIF3 Translation Initiation · correlation 0.95
- RNA Processing Translation · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.