CCDC59 — Coiled-coil domain containing 59
CCDC59 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCDC59's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Ribosome biogenesis Housekeeping | APEX1, APRT, C1QBP, HNRNPA1, IMPDH2, LBH, LDHA, LSM5 +17 more | View in SCUBA |
| Gamma-delta T cells | ER Proteotoxic Stress Stress | ARL4A, BCAS2, CSRNP1, CYCS, EIF5, EXOSC6, FOSB, HSPA5 +13 more | |
| Innate lymphoid cells | RNA Chromatin Regulation RNA processing & translation | BTBD7, CWC25, DDX3Y, DNTTIP2, HNRNPU, KRR1, MRFAP1, PNRC2 +5 more | View in SCUBA |
| Macrophages | RNA Processing & Repair Housekeeping | BRD7, CCT4, CCT6A, CNDP2, EIF3J, EIF5B, EMC4, EPRS1 +31 more | View in SCUBA |
| Mucosal-associated invariant T cell | mRNA Decay Program RNA processing & translation | ATP6V0C, BCL7B, BTG1, BTG3, DDIT4, DUSP2, DYNLL2, EXOSC6 +13 more |
About the gene
| Synonyms | BR22, HSPC128, TAP26 |
|---|---|
| Chromosome | 12: 82223681-82358805 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Transcription, Transcription regulation |
Function
Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.