KRR1 — KRR1 small subunit processome component homolog

KRR1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

KRR1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Transcriptional regulation DNA/chromatin regulation	CCNH, CWC25, DYNLL2, EIF2A, GOLGB1, IVNS1ABP, JMJD1C, LPIN2 +8 more	View in SCUBA
Gamma-delta T cells	Hypoxia Stress Response Stress	ARIH2, BNIP2, C9orf78, CHD4, FBXO7, HIF1A, HNRNPH1, JADE1 +16 more
Innate lymphoid cells	RNA Chromatin Regulation RNA processing & translation	BTBD7, CCDC59, CWC25, DDX3Y, DNTTIP2, HNRNPU, MRFAP1, PNRC2 +5 more	View in SCUBA
Macrophages	Protein Biogenesis Housekeeping	ATP6V0D1, B3GAT3, BUD23, C11orf58, CHD4, CNPY2, DAZAP1, DDX46 +23 more	View in SCUBA
Mucosal-associated invariant T cell	Metabolic Homeostasis Housekeeping	ADIPOR1, BIRC3, COQ10B, CREBRF, EIF1AX, GNAI3, H2AC20, KLF11 +10 more

About the gene

Synonyms	HRB2, RIP-1
Chromosome	12: 75490863-75511636
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Plasma proteins, Predicted intracellular proteins
Molecular function	Ribonucleoprotein, RNA-binding
Biological process	Ribosome biogenesis, rRNA processing

Function

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.