SWI-SNF DNA Repair
Gene co-expression module in Colonocytes
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 30 genes have a known function matching the annotation |
Why this annotation
EIF3A and EIF3B (top hubs, eIF3 complex) link this module to its neighbor M96. However, the defining feature here is the SWI-SNF chromatin remodeling complex (SMARCA5/SNF2H, SMARCC1) combined with DNA repair enzymes (PRKDC/DNA-PKcs, PARP1). SYNCRIP/hnRNPQ, ILF3, RBMX, HNRNPA0 are RNA-binding proteins. IPO7 (importin 7, nuclear import of histones/ribosomal proteins), TCERG1 (transcription elongation), CEBPZ (rDNA transcription), NFIA (transcription factor), DDX18 (RNA helicase, rRNA processing), MPHOSPH10 (rRNA processing) round out the module. The co-occurrence of SWI-SNF remodeling with DNA repair in crypt colonocytes suggests a chromatin accessibility/DNA damage response program active during proliferation.
Genes
Most correlated modules
- Ribosome Biogenesis · correlation 0.96
- SUMOylation Chromatin · correlation 0.96
- DNA Repair Housekeeping · correlation 0.94
- Ribosome Biogenesis · correlation 0.93
- Chaperone Proteostasis · correlation 0.93
- CCT Chaperonin Folding · correlation 0.93
- snRNP Splicing · correlation 0.92
- Splicing Regulation · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.