NF-κB Oxidative Stress

Gene co-expression module in Endothelial

View this module in SCUBA

Why this annotation

IKBIP (IKK-β interacting protein) directly links this module to NF-κB inflammatory signaling. CDKN3 and CDC25B are cell cycle phosphatases suggesting proliferative activation. PRDX4 and GPX8 are ER-localized oxidoreductases responding to oxidative/ER stress. SSR3 is a translocon component. ARHGDIB (Rho GDI β) regulates Rho GTPases in inflammatory signaling. ITGAE (CD103/integrin αE) is expressed on activated endothelium in inflammatory contexts. LDHB reflects metabolic reprogramming. EZR (ezrin) links membrane to cytoskeleton. MRPS33 is mitochondrial. The module is moderately coherent with mixed membership scores, suggesting it combines NF-κB/ER stress with cell cycle components. Inflammation delta is moderate (0.47 UC). In the context of neighboring modules, this represents the NF-κB/oxidative stress arm of the inflammatory response.

Genes

ACP1, ALDH7A1, ARHGDIB, CCDC85C, CDC25B, CDKN3, CMSS1, COPRS, CYTL1, DNAJC15, EZR, GPX8, IKBIP, ITGAE, LDHB, MRPS33, NREP, NUP37, PABPC4, PRDX4, SSR3, UHRF2

Most correlated modules

• Inflammatory Endothelial Activation · correlation 0.89
• Spliceosome snRNP Assembly · correlation 0.85
• ER-Golgi Trafficking · correlation 0.85
• Glycolysis Activation · correlation 0.83
• Hypoxia Response · correlation 0.83
• Nuclear Transport · correlation 0.83
• Wnt Angiogenic Remodeling · correlation 0.81
• Nuclear Transport · correlation 0.81

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.