Hypoxia Response
Gene co-expression module in Endothelial
| Category | Stress |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
Hub gene HIF1A is the master hypoxia transcription factor. Supporting genes include CRELD2 (ER stress/UPR induced by hypoxia), RAB13 (tight junction/vesicle trafficking regulated by hypoxia), NECTIN2 (cell adhesion upregulated in inflammatory hypoxia), LAPTM4B (lysosomal membrane protein upregulated by HIF1A), SPCS3 (signal peptidase in ER, co-regulated with HIF1A targets), FKBP1A (regulates HIF1A stability). Module is upregulated in UC/CD inflammation and reversed in remission, consistent with hypoxic microenvironment during intestinal inflammation. Neighbor context: this module represents the hypoxia arm of the broader inflammatory endothelial response seen across this batch.
Genes
C1orf122, CRELD2, CSTB, EFHD2, FKBP1A, HIF1A, LAPTM4B, NECTIN2, RAB13, RNF145, SPCS3, TPM3
Most correlated modules
- ER Protein Processing · correlation 0.92
- Inflammatory Endothelial Activation · correlation 0.90
- UPR / ER Stress · correlation 0.88
- Proteasomal Degradation · correlation 0.86
- Actin Vesicle Trafficking · correlation 0.86
- Glycolysis Activation · correlation 0.85
- NF-κB Oxidative Stress · correlation 0.83
- Mitochondrial OxPhos · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.