Endothelial Quiescence Identity
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include FOXF1 (forkhead transcription factor essential for vascular endothelial identity and quiescence), VWF (von Willebrand factor, canonical endothelial marker), FZD4 (Frizzled-4, Wnt receptor critical for vascular development and blood-retinal/intestinal barrier), IGFBP7 (marker of quiescent/arterial endothelium), MATN2 (ECM glycoprotein expressed in vascular walls), and KCNE4 (potassium channel subunit). RBP5 (retinol binding protein) and CLSTN3 (adhesion/signaling) are additional members. The module has higher baseline expression and lower inflammation delta compared to neighbors, consistent with a constitutive endothelial identity program. The mild inflammation signal likely reflects partial loss of quiescence in IBD. Contrasts with M61/M108 which represent the activated state.
Genes
CCDC69, CLIC2, CLSTN3, CPD, EPB41L4A, FOXF1, FZD4, IGFBP7, KCNE4, KIAA0040, MATN2, NCOA7, RBP5, S100A13, TNFRSF1A, VWF
Most correlated modules
- Lipid Droplet Hypoxia · correlation 0.75
- Immune Cell Contamination · correlation 0.75
- Leukocyte Recruitment Signaling · correlation 0.74
- Quiescent Arterial EC · correlation 0.74
- Venular Inflammatory Activation · correlation 0.72
- Vasoactive GPCR Signaling · correlation 0.70
- Mitochondrial Metabolic Stress · correlation 0.70
- Wnt Angiogenic Remodeling · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.