Actin Cytoskeletal Remodeling
Gene co-expression module in Endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes ACTR2, ARPC4, CAP1 are core Arp2/3 actin nucleation complex members; ROCK2 is a Rho-associated kinase driving actin stress fibers; PAFAH1B1 (LIS1) regulates dynein/microtubule dynamics. Additional genes include G3BP1 (stress granule assembly), EIF4G1 (translation), FYTTD1 (mRNA export), GSPT1 (translation termination), MOB1A (Hippo/cytoskeletal), IPO7 (nuclear import), XRCC5 (DNA repair), RECQL (DNA helicase), ANKRD11 (chromatin). The dominant cytoskeletal actin remodeling program is supported by multiple Arp2/3 components and ROCK2. Significantly upregulated in UC and CD inflammation. Neighbor modules share inflammation upregulation; the actin/cytoskeletal remodeling distinguishes M66 as reflecting endothelial cytoskeletal activation during colitis.
Genes
ACTR2, ANKRD11, ARPC4, CAP1, EIF4G1, FYTTD1, G3BP1, GSPT1, IPO7, MOB1A, PAFAH1B1, PSMD10, RECQL, ROCK2, SH3GLB1, TOP1, XRCC5
Most correlated modules
- ER-Golgi Trafficking · correlation 0.90
- Inflammatory Lipid Metabolism · correlation 0.85
- mRNA Splicing Stress · correlation 0.85
- Actin Vesicle Trafficking · correlation 0.85
- Rho-Actin Remodeling · correlation 0.84
- Proteasomal Degradation · correlation 0.83
- Actin Cytoskeletal Remodeling · correlation 0.83
- DNA Damage Repair · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.