ER-Golgi Trafficking
Gene co-expression module in Endothelial
| Category | Protein processing & ER |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
TM9SF3 (transmembrane 9 superfamily member 3, lysosomal/Golgi), KTN1 (kinectin, ER-kinesin anchor for ER tubule extension), TRAM1 (translocon-associated membrane protein, co-translational ER import), MAGT1 (magnesium transporter required for N-glycosylation in ER), ATL3 (atlastin-3 GTPase, ER tubule fusion and morphology), and GOLIM4 (Golgi integral membrane protein 4) collectively define an ER-to-Golgi membrane trafficking and ER morphology program. ECE1 (endothelin-converting enzyme 1) is a canonical endothelial marker processed through the secretory pathway. DIAPH2 (formin) links to the actin neighborhood. SLK is a kinase involved in cytoskeletal regulation. PGK1 is a glycolytic enzyme. The ER/Golgi trafficking theme is the most coherent program.
Genes
ATL3, DIAPH2, ECE1, EID1, GOLIM4, KTN1, MAGT1, PGK1, SHISA5, SLK, STRAP, TM9SF3, TRAM1
Most correlated modules
- Actin Cytoskeletal Remodeling · correlation 0.90
- Chromatin Cell Cycle · correlation 0.83
- Rho-Actin Remodeling · correlation 0.82
- UPR / ER Stress · correlation 0.82
- Inflammatory Lipid Metabolism · correlation 0.81
- IL-13/STAT6 Signaling · correlation 0.81
- DNA Damage Repair · correlation 0.80
- Oxidative Stress Response · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.