Vascular Barrier Integrity
Gene co-expression module in Endothelial
| Category | migration & adhesion |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
ROBO4 is a highly endothelial-specific roundabout receptor that maintains vascular integrity and suppresses pathological angiogenesis. LAMB1 (laminin beta1) anchors endothelial cells to BM. TNS3 (tensin-3) localizes to focal adhesions linking integrins to actin. DYSF (dysferlin) mediates membrane repair. MYO1B and MYO6 (unconventional myosins) regulate endocytic trafficking and cell shape. TRIOBP organizes actin at cell junctions. GJA1 (connexin 43) forms gap junctions for endothelial communication. SCARF1 is an endothelial scavenger receptor. HDAC1 regulates endothelial gene expression. The moderate inflammation signal and broad uniform expression suggest a vascular integrity/barrier maintenance program.
Genes
APCDD1, CREB3L2, DYSF, GJA1, GRAMD1A, HDAC1, IGF2R, LAMB1, LGMN, MYO1B, MYO6, PPM1F, PTPA, RAB11A, ROBO4, SCARF1, SPG7, TMEM255B, TNS3, TRIOBP
Most correlated modules
- Basement Membrane Assembly · correlation 0.89
- Coagulation Protease Signaling · correlation 0.85
- Inflammatory EC Activation · correlation 0.84
- ECM Fibrotic Remodeling · correlation 0.80
- Actomyosin Contractility · correlation 0.76
- Angiogenic Endothelial Identity · correlation 0.74
- Arterial EC Identity · correlation 0.74
- Venous Endothelial Identity · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.