Inflammatory Kinase Signaling
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 16 genes have a known function matching the annotation |
Why this annotation
Hub gene MAP4K4 is a stress-activated MAPK kinase central to TNF-induced endothelial inflammation and barrier disruption. TNFRSF25 is a TNF receptor superfamily member activating NF-κB/apoptosis. FYN is a Src-family kinase in inflammatory signaling. CBL is an E3 ubiquitin ligase mediating receptor downregulation. VCL (vinculin) and MYO1E (myosin IE) are cytoskeletal components remodeled during inflammatory activation. VASH1 is an anti-angiogenic factor upregulated in inflamed endothelium. CNN2 (calponin-2) participates in actin cytoskeletal regulation. The module is significantly upregulated in both UC and CD inflammation with no treatment reversal, consistent with a sustained inflammatory kinase signaling program in endothelial cells. Neighbor context: all batch modules are inflammation-associated; M19 represents the kinase/receptor signaling arm.
Genes
ANKRD28, CBL, CDC123, CNN2, DGKH, EOGT, FADS3, FYN, MAP4K4, MYO1E, NAV1, PRKAR2A, SMARCA5, TNFRSF25, VASH1, VCL
Most correlated modules
- Endocytic Membrane Remodeling · correlation 0.88
- ER Calcium Stress · correlation 0.83
- Actomyosin Contractility · correlation 0.82
- Vascular Tone Regulation · correlation 0.81
- Endothelial Membrane Transport · correlation 0.79
- Inflammatory Lipid Metabolism · correlation 0.78
- Inflammatory EC Activation · correlation 0.77
- Actin Cytoskeletal Remodeling · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.