UPR / ER Stress
Gene co-expression module in Endothelial
| Category | Protein processing & ER |
|---|---|
| Genes | 19 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 15 of 19 genes have a known function matching the annotation |
Why this annotation
This module is a textbook unfolded protein response (UPR) / ER stress signature. Hub genes: HSP90B1 (GRP94, ER Hsp90 chaperone), PDIA3/PDIA4/PDIA6 (protein disulfide isomerases), HYOU1 (ORP150/GRP170, ER Hsp70 family), CALR (calreticulin, ER Ca2+ buffer and chaperone), VCP/p97 (AAA-ATPase driving ERAD retrotranslocation), HSPA5 (BiP/GRP78, master UPR sensor), CANX (calnexin, lectin chaperone), RPN1 (OST complex, N-glycosylation), SURF4 (ER-Golgi cargo receptor), MANF (ER stress-secreted neurotrophic factor), SDF2L1 (ER stress marker), SEC61A1 (translocon alpha subunit), PDIA6, MYDGF (ER-derived cardioprotective factor). Nearly every high-PageRank gene is a canonical ER chaperone or ERAD component. Upregulation in IBD inflammation reflects increased secretory protein load and ER stress in activated endothelial cells. This is the core UPR module; M23 and M123 are its neighbors representing constitutive ER processing and proteasomal clearance respectively.
Genes
CALR, CANX, CTSB, CTTN, GRN, HDLBP, HSP90B1, HSPA5, HYOU1, MANF, MYDGF, PDIA3, PDIA4, PDIA6, RPN1, SDF2L1, SEC61A1, SURF4, VCP
Most correlated modules
- Glycolysis Activation · correlation 0.92
- Proteasomal Degradation · correlation 0.92
- ER Protein Processing · correlation 0.90
- Mitochondrial OxPhos · correlation 0.89
- mRNA Splicing Stress · correlation 0.88
- Hypoxia Response · correlation 0.88
- ER-Golgi Trafficking · correlation 0.87
- Mitochondrial OxPhos · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.