Actomyosin Contractility
Gene co-expression module in Endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
MPRIP (myosin phosphatase Rho-interacting protein) directly regulates actomyosin contractility by anchoring myosin phosphatase to actin stress fibers. CAPN2 (calpain-2) is a calcium-dependent protease that cleaves cytoskeletal proteins during cell contraction and permeability changes. GNB2 (G-protein β2 subunit) mediates GPCR signaling upstream of Rho/actomyosin. PEA15 modulates ERK and apoptosis signaling. INPP5A regulates inositol phosphate/Ca²⁺ signaling. NID1 (nidogen-1) is a basement membrane component whose remodeling accompanies cytoskeletal changes. The module is upregulated in both UC and CD inflammation, consistent with inflammatory cytokine-driven endothelial contraction and barrier disruption. The actomyosin/GPCR/Ca²⁺ axis is a well-established mediator of vascular permeability in inflammation.
Genes
BCAP29, CAPN2, GNB2, INPP5A, ITPRIPL2, LGALS1, LRRC8C, MPRIP, NID1, PEA15, TMEM109
Most correlated modules
- Integrin-Actin Adhesion · correlation 0.86
- Mitophagy Stress Response · correlation 0.83
- Inflammatory EC Activation · correlation 0.83
- Inflammatory Kinase Signaling · correlation 0.82
- Inflammatory Lipid Metabolism · correlation 0.82
- Angiogenic Endothelial Identity · correlation 0.81
- Endocytic Membrane Remodeling · correlation 0.78
- Vascular Barrier Integrity · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.