Inflammatory Lipid Metabolism
Gene co-expression module in Endothelial
| Category | Metabolite transfer |
|---|---|
| Genes | 14 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
APOL1 (apolipoprotein L1, lipid droplet/immune defense), ACSL4 (acyl-CoA synthetase long chain 4, arachidonic acid metabolism and ferroptosis), NPC1 (Niemann-Pick C1, intracellular cholesterol transport), and ELOVL5 neighbor (fatty acid elongation) define a lipid metabolism and intracellular lipid trafficking program. GOLM1 (Golgi membrane protein 1) and WDFY1 (FYVE domain endosomal protein) support vesicular lipid transport. SGCB (sarcoglycan beta) is a membrane-associated structural protein. MAPRE1 (EB1, microtubule plus-end tracking) and RB1 (retinoblastoma protein) are cell cycle/cytoskeletal regulators. CDK2AP2 and COPS8 (COP9 signalosome) are involved in protein degradation. SELENOK is an ER selenoprotein. The strong inflammation upregulation (delta UC 0.44, CD 0.37) with remission reversal suggests this lipid program is inflammation-induced, consistent with APOL1 and ACSL4 roles in inflammatory lipid signaling.
Genes
ACSL4, APOL1, CDK2AP2, COPS8, GBE1, GOLM1, MAPRE1, NPC1, PDLIM7, RB1, S100A3, SELENOK, SGCB, WDFY1
Most correlated modules
- ER Calcium Stress · correlation 0.89
- Rho-Actin Remodeling · correlation 0.88
- Actin Cytoskeletal Remodeling · correlation 0.88
- Actin Vesicle Trafficking · correlation 0.87
- Actin Cytoskeletal Remodeling · correlation 0.85
- Proteasomal Degradation · correlation 0.84
- Inflammatory EC Activation · correlation 0.82
- Actomyosin Contractility · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.