Respiratory Chain OXPHOS
Gene co-expression module in Enterocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 7 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 6 of 7 genes have a known function matching the annotation |
Why this annotation
Hub genes are core OXPHOS subunits: complex I (NDUFS5, NDUFB9, NDUFS6), complex III (UQCRFS1, UQCRH) and ATP synthase (ATP5MC1). TXN adds a redox link. Expression is uniform and highly detected, consistent with a baseline respiratory chain program in enterocytes. Neighbors M72 and M70 are also OXPHOS modules.
Genes
ATP5MC1, NDUFB9, NDUFS5, NDUFS6, TXN, UQCRFS1, UQCRH
Most correlated modules
- Electron Transport Chain · correlation 0.95
- ATP Synthase OXPHOS · correlation 0.94
- Respiratory Chain Subunits · correlation 0.92
- Oxidative Phosphorylation · correlation 0.86
- Mitochondrial Chaperonin · correlation 0.85
- Abundant Transcript Baseline · correlation 0.84
- Translation Elongation · correlation 0.84
- Mitochondrial Energy Metabolism · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.