SCUBA

NDUFS6 — NADH:ubiquinone oxidoreductase subunit S6

NDUFS6 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NDUFS6's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsOxidative Phosphorylation
Mitochondrial & OxPhos
AP2S1, ATP5F1C, ATP5PF, COPS9, COX6B1, EID1, FAM89B, FDPS +19 moreView in SCUBA
CD8⁺ T cellsComplex I / OXPHOS
Mitochondrial & OxPhos
DAD1, GSTO1, GTF3C6, MANF, NDUFA12, NDUFA4, NDUFAB1, NDUFB3 +1 moreView in SCUBA
EndothelialMitochondrial OxPhos
Mitochondrial & OxPhos
ARPC1B, ATP5MF, AURKAIP1, NDUFB2, PARVB, PFN1, POLR2E, SERF2 +3 moreView in SCUBA
EnterocytesRespiratory Chain OXPHOS
Mitochondrial & OxPhos
ATP5MC1, NDUFB9, NDUFS5, TXN, UQCRFS1, UQCRHView in SCUBA
Gamma-delta T cellsComplex I Assembly
Mitochondrial & OxPhos
AKR7A2, AP2S1, BLOC1S1, DCTN2, HSD17B10, LAMTOR2, MGMT, MRPL34 +13 more
Goblet cellsElectron Transport Chain
Mitochondrial & OxPhos
ATP5IF1, ATP5ME, COX5B, DCXR, NDUFA2, NDUFA3, NDUFB1, NDUFB10 +5 moreView in SCUBA
Innate lymphoid cellsMitochondrial OxPhos Biogenesis
Mitochondrial & OxPhos
AP1S1, ATOX1, ATP5ME, ATP5MF, C1QBP, CNIH1, CYC1, ERH +22 moreView in SCUBA
Lymphatic endothelialMitochondrial OxPhos Complex
Mitochondrial & OxPhos
ANAPC11, AP2M1, BRK1, LSM3, MRPL51, MRPS21, NDUFA12, NDUFAB1 +6 moreView in SCUBA
MacrophagesSpliceosomal snRNP
Cell cycle
ANAPC11, BANF1, CCDC25, CCT8, ERH, FIBP, FKBP3, GLRX5 +30 moreView in SCUBA
Mucosal-associated invariant T cellMitochondrial Ribosome
Mitochondrial & OxPhos
AGTRAP, BRK1, C11orf68, C14orf119, CNPY2, CZIB, DCTPP1, DYNC1I2 +22 more

About the gene

SynonymsCI-13kA
Chromosome5: 1801407-1816048
Predicted locationIntracellular
Essential geneNo
Protein classDisease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Biological processElectron transport, Respiratory chain, Transport

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.