SCUBA

NDUFS5 — NADH:ubiquinone oxidoreductase subunit S5

NDUFS5 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NDUFS5's module in each cell type

Cell typeModuleShares the module with
EndothelialMitochondrial OxPhos
Mitochondrial & OxPhos
ARPC3, CLTB, COX6A1, COX7A2, COX7B, DAD1, ELOB, MYL12B +9 moreView in SCUBA
EnterocytesRespiratory Chain OXPHOS
Mitochondrial & OxPhos
ATP5MC1, NDUFB9, NDUFS6, TXN, UQCRFS1, UQCRHView in SCUBA
FibroblastsActin Cytoskeleton
Cytoskeletal
ACTB, CAPZA2, CFL1, CMTM6, COX8A, KIF5B, MORF4L2, PCBP1 +6 moreView in SCUBA
Gamma-delta T cellssnRNP Splicing
RNA processing & translation
CHCHD2, DAZAP1, GAPDH, GIT1, GUK1, HDGF, ILF2, LAMTOR5 +16 more
Glial cellsProteostasis Stress Response
Stress
ATOX1, ATP5MG, ATP6V0E1, C19orf53, C4orf3, COX7B, CYSTM1, GUK1 +7 moreView in SCUBA
Goblet cellsActin Dynamics
Cytoskeletal
ABRACL, CD24, CFL1, MYL12A, NDUFB4, OCIAD2, PIN4, RTRAF +3 moreView in SCUBA
Hematopoietic progenitor cellsChaperonin TRiC Complex
Housekeeping
ARL2, CCDC85B, CCT2, CCT3, CCT5, CCT6A, GADD45GIP1, NUDC +4 more
Innate lymphoid cellsActin Cytoskeleton Remodeling
Cytoskeleton & motility
APRT, ARPC2, ARPC3, ATP5F1E, ATP6V0E1, C11orf58, CFL1, CHCHD2 +17 moreView in SCUBA
Lymphatic endothelialMitochondrial OxPhos Complex
Mitochondrial & OxPhos
COX6A1, COX6B1, COX6C, COX7A2, COX8A, DAD1, NDUFA1, NDUFB4 +6 moreView in SCUBA
MacrophagesProtein Homeostasis Mixed
Housekeeping
ABRACL, ADI1, AP2S1, ATP5F1B, BRK1, CFL1, CHCHD2, CLTA +33 moreView in SCUBA

About the gene

SynonymsCI-15k
Chromosome1: 39026318-39034636
Predicted locationIntracellular
Essential geneYes
Protein classEssential proteins, Metabolic proteins, Predicted intracellular proteins
Biological processElectron transport, Respiratory chain, Transport

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.