Mitochondrial Energy Metabolism
Gene co-expression module in Enterocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
The module mixes complex III subunits (UQCRC1, UQCRC2), a complex I subunit (NDUFV1) and MTCH2 with metabolic enzymes. The metabolic enzymes are glycolysis (GPI, GALM), aldehyde detoxification (ALDH3A2, ALDH1A1), glutathione conjugation (GSTM4) and the urea cycle/nitrogen enzyme CPS1. Together this reflects coupled carbohydrate and mitochondrial energy metabolism in mature enterocytes. It bridges the OxPhos neighbors (M92, M19) and the detoxification neighbors (M24, M60).
Genes
ALDH1A1, ALDH3A2, CPS1, GALM, GCNT1, GPI, GSTM4, MTCH2, NDUFV1, UQCRC1, UQCRC2
Most correlated modules
- Long-gene nuclear transcripts · correlation 0.86
- Respiratory Chain Subunits · correlation 0.84
- Respiratory Chain OXPHOS · correlation 0.81
- Oxidative Phosphorylation · correlation 0.79
- ATP Synthase OXPHOS · correlation 0.77
- Xenobiotic Detoxification · correlation 0.75
- Carbohydrate Digestion/Detox · correlation 0.75
- Electron Transport Chain · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.