Redox Detoxification
Gene co-expression module in Enterocytes
| Category | Stress |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 12 genes have a known function matching the annotation |
Why this annotation
Hubs combine oxidative stress/detoxification genes (CYBA, TSPO, GSTP1, GSTK1), the inflammasome adaptor PYCARD, and epithelial identity genes (CD9, KRT18, CDX1, SERPINB5, TMSB10). ER translocon genes SEC61B and SSR4 also co-vary. The best reading is an epithelial redox/xenobiotic defense state, possibly reflecting colonocyte stress; it is not contamination since expression is uniform.
Genes
CD9, CDX1, CYBA, GSTK1, GSTP1, KRT18, PYCARD, SEC61B, SERPINB5, SSR4, TMSB10, TSPO
Most correlated modules
- Nucleolar RNA-binding · correlation 0.84
- Translation Elongation · correlation 0.84
- Respiratory Chain OXPHOS · correlation 0.79
- Transit-amplifying progenitor · correlation 0.78
- Abundant Transcript Baseline · correlation 0.77
- IFN-gamma immunoproteasome · correlation 0.76
- Electron Transport Chain · correlation 0.73
- Mitochondrial Chaperonin · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.