Mitochondrial Chaperonin
Gene co-expression module in Enterocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 7 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 7 genes have a known function matching the annotation |
Why this annotation
Hubs include the mitochondrial chaperonin pair HSPD1/HSPE1 together with NDUFB1 and the redox gene MGST1. OST4, TMA7 and HINT1 are small, highly expressed housekeeping genes. The module suggests mitochondrial proteostasis tied to respiratory activity, adjacent to the OXPHOS neighbors.
Genes
HINT1, HSPD1, HSPE1, MGST1, NDUFB1, OST4, TMA7
Most correlated modules
- ATP Synthase OXPHOS · correlation 0.91
- Translation Elongation · correlation 0.88
- Electron Transport Chain · correlation 0.86
- Respiratory Chain OXPHOS · correlation 0.85
- Respiratory Chain Subunits · correlation 0.82
- Abundant Transcript Baseline · correlation 0.81
- Oxidative Phosphorylation · correlation 0.81
- Nucleolar RNA-binding · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.