Translation Elongation
Gene co-expression module in Enterocytes
| Category | RNA processing & translation |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
Hubs are translation machinery genes: the nascent-chain complex (NACA, BTF3), RACK1, elongation factors (EEF1A1, EEF1B2), EIF3E, YBX1, PFDN5 and PPIA. Mitochondrial genes (ATP5MC2, ATP5F1E, TOMM7, SLC25A6, NDUFC2) co-vary, reflecting a general biosynthetic/abundance axis shared with the OXPHOS neighbors.
Genes
ATP5F1E, ATP5MC2, BTF3, EEF1A1, EEF1B2, EIF3E, NACA, NDUFC2, PFDN5, PPIA, RACK1, SLC25A6, TOMM7, YBX1
Most correlated modules
- Mitochondrial Chaperonin · correlation 0.88
- ATP Synthase OXPHOS · correlation 0.85
- Electron Transport Chain · correlation 0.85
- Redox Detoxification · correlation 0.84
- Respiratory Chain OXPHOS · correlation 0.84
- Nucleolar RNA-binding · correlation 0.81
- Abundant Transcript Baseline · correlation 0.81
- Respiratory Chain Subunits · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.