Oxidative Phosphorylation
Gene co-expression module in Enterocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Hubs include complex III and IV subunits (UQCRQ, UQCRB, COX6C, COX6A1), NDUFA1 and SLC25A3 (mitochondrial phosphate carrier). Fatty acid beta-oxidation is represented by ECHS1 and HADHA, and antioxidant/detox genes by MGST3, PRDX1 and DDT. LGALS4 marks the enterocyte background. This is highly expressed baseline mitochondrial respiration in colonocytes, which rely on butyrate oxidation. It is closely allied with M92.
Genes
COX6A1, COX6C, DDT, ECHS1, HADHA, LGALS4, MGST3, NDUFA1, PRDX1, SLC25A3, UQCRB, UQCRQ
Most correlated modules
- Electron Transport Chain · correlation 0.93
- Respiratory Chain Subunits · correlation 0.93
- ATP Synthase OXPHOS · correlation 0.90
- Respiratory Chain OXPHOS · correlation 0.86
- Abundant Transcript Baseline · correlation 0.83
- Mitochondrial Chaperonin · correlation 0.81
- Mitochondrial Energy Metabolism · correlation 0.79
- Enterocyte Ion/Nutrient Transport · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.